EXVIVO FUNCTIONAL-EVALUATION OF PIG HEARTS SUBJECTED TO 24 HOURS PRESERVATION BY HYPOTHERMIC PERFUSION

  • 1 January 1981
    • journal article
    • research article
    • Vol. 60  (6) , 245-248
Abstract
A system was developed for the ex vivo functional testing of isolated hearts. Three groups, each of 10 pig hearts, were studied: group 1 consisted of freshly excised hearts; group 2 of hearts hypothermically perfused for 20-24 h with Krebs-Henseleit solution; group 3 of hearts similarly perfused with a clear fluid hyperosmolar solution. Group 2 hearts performed poorly on functional testing and were clearly unsuitable for transplantation. Hemodynamic observations on group 3 hearts showed little statistical difference from those of group 1, suggesting good preservation. The value of the ex vivo testing system as a reliable means of assessing myocardial function is discussed and has been confirmed by subsequent successful orthotopic transplantation of baboon hearts stored under identical conditions.

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