Inhibition of coal fly ash polycyclic aromatic hydrocarbons and metals induced mixed‐function oxidase activity in rat lung and liver by vitamin A and citrate

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Abstract
Administration of benzene‐soluble fraction (FAE) and benzene‐insoluble fraction (FAR) of fly ash for 3 consecutive days to rats significantly raised cytochrome P‐450 levels, aryl hydrocarbon hydroxylase (AHH) activity, and glutathione S‐transferase activity in liver. This treatment also significantly increased pulmonary AHH and glutathione S‐transferase activity. Intratracheal administration of FAR (5 mg/100 g body weight) alone for 6 consecutive days also significantly increased hepatic cytochrome P‐450 levels and the activity of glutathione S‐transferase. Intragastric administration of retinyl palmitate (5000 IU/100 g body weight), along with intratracheal FAE and FAR administration, significantly reduced P‐450 levels, activity of glutathione S‐transferase in liver, and activity of AHH and glutathione S‐transferase in lung of rats. Intraperitoneal administration of citrate (40 mg/100 g body weight) along with FAR significantly reduced FAR‐induced increase in hepatic cytochrome P‐450 levels and glutathione S‐transferase activity. The activity of AHH was not affected by these treatments.