Immunoregulation in the tissues by γδ T cells
Top Cited Papers
- 1 March 2003
- journal article
- review article
- Published by Springer Nature in Nature Reviews Immunology
- Vol. 3 (3) , 233-242
- https://doi.org/10.1038/nri1030
Abstract
For a T-cell subset to be classified as immunoregulatory, it might reasonably be predicted that in its absence, animals would experience pathological immune dysregulation. Moreover, reconstitution of the subset should restore normal immune regulation. So far, these criteria have been satisfied by only a few of the candidate regulatory T-cell subsets, but among them is the intraepithelial gammadelta T-cell receptor (TCR)+ subset of mouse skin. In this article, we look at immunoregulatory gammadelta T cells, and the growing evidence for tissue-associated immunoregulation mediated by both gammadelta T cells and alphabeta T cells.Keywords
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