Analysis of Erythromycin II. Determination of Erythromycin in Human Blood Serum by Competitive Displacement of [14C]-Erythromycin fromE. ColiRibosomes
- 31 December 1976
- journal article
- research article
- Published by Taylor & Francis in Analytical Letters
- Vol. 10 (9) , 719-731
- https://doi.org/10.1080/00032717708059237
Abstract
A sensitive and selective method for the determination of erythromycin in human blood serum, in the range of 0.1 to 1.0 μg/ml, is described. The procedure is based on extraction of drug into ether and competitive displacement of [14C]-erythromycin from E. coli ribosomes. The method provides accurate, precise and rapid analyses and should be readily adaptable to bioavailability studies with erythromycin and its salts in man.Keywords
This publication has 11 references indexed in Scilit:
- Fluorometric determination of erythromycin and erythromycin propionate in whole blood or plasma and correlation of results with microbiological assayAnalytical Chemistry, 1976
- Binding of [ 14 C]Erythromycin to Escherichia coli RibosomesAntimicrobial Agents and Chemotherapy, 1974
- The intermolecular complex of erythromycin and ribosomeJournal of Molecular Biology, 1969
- Reactivity of some hydroxyketones with blue tetrazoliumAnalytical Chemistry, 1961
- Assay of Antibiotics in Small Amounts of FluidScandinavian Journal of Clinical and Laboratory Investigation, 1960
- Erythromycin. II. Des-N-methylerythromycin and N-Methyl-C14-erythromycinJournal of the American Chemical Society, 1955
- Determination of Erythromycin by Ultraviolet SpectrophotometryAnalytical Chemistry, 1955
- Colorimetric Method for Determination of Aureomycin, Carbomycin, Erythromycin, and Terramycin in Aqueous SolutionScience, 1953
- Colorimetric Determination of ErythromycinAnalytical Chemistry, 1953