Sildenafil increases cerebrovascular reactivity: A transcranial Doppler study
- 27 September 2005
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 65 (6) , 919-921
- https://doi.org/10.1212/01.wnl.0000173835.12308.bb
Abstract
The authors performed a double-blind, placebo-controlled study in 28 patients to evaluate the effects of sildenafil on cerebral hemodynamics. A significant improvement of cerebrovascular reactivity, without any modification of other variables, was recorded 1 hour after the administration of 50 mg sildenafil. Further investigations are needed to evaluate whether cerebrovascular reactivity improvement could contribute to triggering sildenafil-induced migraine.Keywords
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