Structure of serum response factor core bound to DNA
- 1 August 1995
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 376 (6540) , 490-498
- https://doi.org/10.1038/376490a0
Abstract
The human serum response factor is a transcription factor belonging to the MADS domain protein family with members characterized from the plant and animal kingdoms. The X-ray crystal structure of the serum response factor core in a specific-recognition DNA complex shows that the functions of DNA binding, dimerization and accessory-factor interaction are compactly integrated into a novel protein unit. The intrinsic and induced conformation of the serum response element DNA is the principal DNA feature recognized in the specific complex.Keywords
This publication has 50 references indexed in Scilit:
- The MADS-Box Family of Transcription FactorsEuropean Journal of Biochemistry, 1995
- Pleiotropic effect of the human T-cell leukemia virus Tax protein on the DNA binding activity of eukaryotic transcription factors.Proceedings of the National Academy of Sciences, 1993
- Interaction between NF-kappa B- and serum response factor-binding elements activates an interleukin-2 receptor alpha-chain enhancer specifically in T lymphocytes.Molecular and Cellular Biology, 1993
- Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors.Genes & Development, 1992
- Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response elementCell, 1992
- Ets-related protein Elk-1 is homologous to the c-fos regulatory factor p62TCFNature, 1991
- Genetic Control of Flower Development by Homeotic Genes in Antirrhinum majusScience, 1990
- Occupation of the c-fos serum response element in vivo by a multi-protein complex is unaltered by growth factor inductionNature, 1989
- Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response elementCell, 1988
- Upstream regions of the human cardiac actin gene that modulate its transcription in muscle cells: presence of an evolutionarily conserved repeated motif.Molecular and Cellular Biology, 1986