Tumor Necrosis Factor-α and Disease Progression in Multiple Sclerosis

Publisher Website
Google Scholar
Abstract
The study by Sharief and Hentges (Aug. 15 issue)1 provides evidence that cerebrospinal fluid levels of tumor necrosis factor-α are higher in patients with chronic progressive multiple sclerosis than in patients with stable disease and that cerebrospinal fluid levels of tumor necrosis factor-α are correlated with disease progression in chronic progressive multiple sclerosis. On the basis of these results the authors suggest that tumor necrosis factor-α has a role in the progression of multiple sclerosis. We believe that the authors should provide additional information concerning the HLA Class II typing of the patients studied, for the following reasons.

This publication has 11 references indexed in Scilit: