The fine specificity of regulatory T cells IV. Idiotypic complementarity and antigen‐bridging interactions in the anti‐lysozyme response

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Abstract
The hen egg‐white lysozyme (HEL)‐specific B cells which are activated in response to HEL share a cross‐reactive idiotype as well as submolecular specificity. Helper T cells of two different specificities are implicated in their optimal activation, one recognizing the idiotype and the other, an epitope on the HEL molecule opposite to the one recognized by B cells. Thus, efficient T‐B collaboration involves both idiotypic complementarity and antigen bridging.
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