Capillary basement membrane changes in adolescents with type 1 diabetes

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Abstract
Measurements were made of muscle capillary basement membrane thickness (CBMT) in 95 normal boys and girls and 167 postpubescent insulin-dependent diabetics. Of 110 diabetics in whom higher degrees of metabolic control were maintained, only 2 had increased CBMT values. Of 57 diabetics in whom lower degrees of metabolic control were maintained, 26 had increased CBMT values. Two or more muscle biopsies were done in each of 65 diabetic subjects. Mean CBMT values of 24 subjects with higher degrees of metabolic control for 2-9 yr remained within the normal range; values of 23 subjects with lower degrees of metabolic control for only 1-3 yr increased from 858 .+-. 142 to 1155 .+-. 227 .ANG.. Values of 13 subjects who had been in lower degrees of control decreased from 1255 .+-. 232 to 869 .+-. 135 .ANG. after maintaining improved metabolic control for .apprx. 1 yr. In postpubescent diabetics the CBMT is labile and progresses or regresses depending on the degree of metabolic control.