THE EFFECT OF BUFFER LOADING UPON AMMONIUM EXCRETION IN THE DOG*

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Abstract
Sodium phosphate (pH 7.4) was administered intravenously to dogs under conditions of relatively constant urine pH.'' It was found that ammonium excretion was entirely independent of the buffer content of the urine and the rate of titratable acid excretion. Although this observation does not allow any conclusion concerning the intimate nature of ammonium transport into the urine, it suggests that ammonium excretion may be dissociated from total hydrogen ion excretion. Furthermore, the avail-ability of hydrogen ions does not appear to constitute a limiting factor in the accumulation of ammonium in the urine.