Improvement of Dissolution Characteristics of Piromidic Acid by Dimethly - β - Cyclodextrin Complexation

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Abstract
Inclusion complex formation of piromidic acid (PA) with dimethyl-β- Cyclodextrin (DM-β-CyD) in aqueous solution and in solid state was confirmed by solubility method, power x-ray diffractometry. The apparent stability constant, Kc, of the complex was estimated as 244 M The stoichiometry of complex was given as the ratio 1:2 PA to DM-β-CyD. The inclusion complex was prepared two different methods, coprecipitation an neutralization. The dissolution rate of PA/DM-β-CyD complexes were dissolved much more rapidly than intact PA.