In vitro infection of human primary adipose cells with HIV-1
- 1 November 2003
- journal article
- research article
- Published by Wolters Kluwer Health in AIDS
- Vol. 17 (17) , 2537-2539
- https://doi.org/10.1097/00002030-200311210-00019
Abstract
We reassessed the infection ability of human primary preadipocytes. The use of X4, R5 or VSV-G-pseudotyped viral particles indicated that viral entry is the limiting step. However, transfection with HIV-1 receptors restored efficient infection. Analyses of CD4, CXCR4 and CCR5 expression on preadipocytes and adipocytes revealed that receptor co-expression levels did not permit HIV-1 entry into adipose cells from all biopsies tested. We concluded that adipose tissue cannot be infected with HIV-1 in vivo.Keywords
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