Antinociceptive Mechanism of the Actonitine Alkaloids Mesaconitine and Benzoylmesaconine
- 1 October 1994
- journal article
- research article
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 60 (05) , 391-394
- https://doi.org/10.1055/s-2006-959516
Abstract
We explored the possible role of the specific regions in the brain stem on the antinociceptive actions of mesaconitine (MA) and benzoylmesaconine (BM) by the microinjection of MA and BM into nucleus reticularis paragigantocellularis (NRPG), nucleus raphe magnus (NRM), and periaqueductal gray (PAG). MA microinjected into NRPG, NRM, or PAG elicited a dose-dependent antinociceptive action, whereas BM injected into NRM or PAG elicited a dose-dependent antinociceptive action but not in NRPG. The NRM appeared to be the most sensitive region among the three tested locations.Keywords
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