IMMUNOMODULATORY EFFECT OF VARIOUS MOLECULAR-WEIGHT MALEIC ANHYDRIDE-DIVINYL ETHERS AND OTHER AGENTS INVIVO

  • 1 January 1980
    • journal article
    • research article
    • Vol. 40  (6) , 1967-1972
Abstract
Various MW maleic anhydride-divinyl ether copolymer polyanions [MVE] were evaluated in 6 in vivo systems. Low and high MW MVE were effective adjuvants with irradiated L1210 [mouse leukemia] tumor cell vaccine. A high percentage of L1210-challenged survivors were refractory to a second challenge of tumor cells. Azimexon and BCG were also effective adjuvants, but bestatin was without adjuvant effect. All the MVE demonstrated a marginal antitumor effect against the L1210 and LSTRA tumors. The MVE, regardless of MW differences, were effective in enhancing macrophage tumoricidal activity and retarding the development of M109 tumor growth in the lungs. Enhancement of delayed-type hypersensitivity by all 6 MVE indicates their ability to stimulate T[thymus-derived] cells.