Biochemical Effects of Cholera Enterotoxin. II. Glucose Metabolism in the Intestine of the Infant Rabbit

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Abstract
The metabolism of glucose in the jejunum of infant rabbits was investigated. Production of lactic acid by jejunal segments from animals with experimental cholera was significantly higher than that by segments from control animals. Addition of enterotoxin in vitro, however, did not affect glycolytic activity. There was no alteration in the amount of CO2 released from 1-14C or 6-14C glucose. These data indicate that glycolysis is significantly increased in the course of experimental cholera in infant rabbits. It is possible that energy derived from the glycolytic pathway may then be used during the process of secretion of fluid by the choleraic, small intestinal mucosa. Oxidative pathways, including the hexose monophosphate shunt, appear not to be involved.

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