ANTITUMOR, ANTIVIRAL AND NATURAL KILLER-INDUCING ACTIVITIES OF HUMAN RECOMBINANT INTERFERON-ALPHA IN THE GUINEA PIG
- 1 January 1986
- journal article
- research article
- Published by Editorial Committee of Japanese Journal of Infectious Diseases, National Institute of Infectious Dis in Japanese Journal of Medical Science and Biology
- Vol. 39 (2) , 97-103
- https://doi.org/10.7883/yoken1952.39.97
Abstract
It was found that human recombinant interferon-alpha (Hu rIFN-.alpha.) was biologically active in the guinea pig. Namely, intratumor injection of either Hu rIFN-.alpha. A or A/D regressed tumors and prevented metastasis of guinea-pig line 10 tumor. These rIFNs augmented splenic natural killer activity of the guinea pig and reduced the cytopathic effect of virus on guinea-pig cells. Hu IFN-.gamma. showed no such activity.This publication has 3 references indexed in Scilit:
- Specific molecular activities of recombinant and hybrid leukocyte interferons.Journal of Biological Chemistry, 1982
- The structure of eight distinct cloned human leukocyte interferon cDNAsNature, 1981
- Human leukocyte interferon produced by E. coli is biologically activeNature, 1980