Novel Combination of Cyclooxygenase-2 and MEK Inhibitors in Human Hepatocellular Carcinoma Provides a Synergistic Increase in Apoptosis
- 1 December 2003
- journal article
- research article
- Published by Elsevier in Journal of Gastrointestinal Surgery
- Vol. 7 (8) , 1024-1033
- https://doi.org/10.1016/j.gassur.2003.09.009
Abstract
No abstract availableKeywords
This publication has 10 references indexed in Scilit:
- Proapoptotic and antiproliferative potential of selective cyclooxygenase-2 inhibitors in human liver tumor cellsHepatology, 2002
- Expression of survivin during liver regenerationBiochemical and Biophysical Research Communications, 2002
- NS‐398, a selective cyclooxygenase 2 inhibitor, inhibited cell growth and induced cell cycle arrest in human hepatocellular carcinoma cell linesInternational Journal of Cancer, 2002
- Increased expression of cyclooxygenase-2 protein during rat hepatocarcinogenesis caused by a choline-deficient, L-amino acid-defined diet and chemopreventive efficacy of a specific inhibitor, nimesulideCarcinogenesis: Integrative Cancer Research, 2002
- Expression and Role of Bcl–Xl in Human Hepatocellular CarcinomasHepatology, 2001
- Expression of cyclooxygenase-2 (COX-2) in hepatocellular carcinoma and growth inhibition of hepatoma cell lines by a COX-2 inhibitor, NS-398.2001
- Inhibition of extracellular signal-regulated kinase 1/2 phosphorylation and induction of apoptosis by sulindac metabolites.2001
- Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathwayOncogene, 1999
- Regulation of Bad Phosphorylation and Association with Bcl-xL by the MAPK/Erk KinaseJournal of Biological Chemistry, 1999
- Rising Incidence of Hepatocellular Carcinoma in the United StatesNew England Journal of Medicine, 1999