Subacute Toxicity of RDX and TNT in Dogs

Abstract
Dogs given daily dosages of RDX of 0.1, 1 or 10 mg/kg/day for 90 days developed no signs of toxicity other than temporary episodes of emesis to which a tolerance apparently developed. One medium level animal died for reasons unrelated to the study. Dogs given daily dosages of TNT of 0.02, 0.1 or 1 mg/kg/ day for 90 days developed no signs of toxicity other than temporary episodes of emesis to which tolerance apparently developed. Laboratory diagnostic procedures and both gross and microscopic postmortem examinations revealed no important differences from controls.

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