Biologically Active Principles of Crude Drugs : Pharmacological Actions of Swertia japonica Extracts, Swertiamarin and Gentianine

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Abstract
The pharmacological effect of a methanolic extract of S. japonica, swertiamarin being the main secoiridoid glucoside of this herb and gentianine obtained from swertiamarin in aqueous ammonia, were investigated in mice and rats. Gentianine exerted depression of the CNS, anti-ulcerogenic action and inhibitory action against gastric secretion, whereas the others had no appreciable action.