TESTS OF PANCREATIC FUNCTION USING SE-75-SELENOMETHIONINE

  • 1 January 1976
    • journal article
    • research article
    • Vol. 23  (2) , 144-150
Abstract
Pancreatic function was investigated in 43 patients using a combination of conventional and subtraction scans of the pancreas and duodenal aspiration of the 75Se-Selenomethionine injected, in the time periods 60-150 min, 90-120 min and 105-150 min after injection. Patients with chronic alcoholism, chronic pancreatitis, pancreatic carcinoma, extrahepatic biliary obstruction and liver disease were included. Seven patients with no evidence of gastro-intestinal disease served as controls. Pancreatic scanning provided 8 false positive and 2 false negative results (23.3%) and with 75Se-selenomethionine excretion at 105-150 min, 6 false results were obtained (14%). In only 1 patient was a false positive result obtained with both scans and the 75Se-selenomethionine test. The performance of conventional and subtraction scans of the pancreas with measurement of 75Se-selenomethionine activity in the duodenal aspirate collected from 105-150 min after injection provides a convenient means of testing pancreatic exocrine function in a single 3 h session.

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