PLACENTAL NA+, K+ACTIVATED ATP-ASE ACTIVITY IN SHRSP IN CONNECTION WITH PREGNANCY INDUCED HYPERTENSION AND INTRA-UTERINE GROWTH RETARDATION
- 1 November 1995
- journal article
- Published by Wiley in Clinical and Experimental Pharmacology and Physiology
- Vol. 22 (s1) , S283-S285
- https://doi.org/10.1111/j.1440-1681.1995.tb02919.x
Abstract
1. Placental Na+, K+‐ATPase activities were measured in connection with the active transport of amino acid, intrauterine growth retardation (IUGR) or small for date infants (SFD) in salt‐loaded pregnant SHRSP. 2. All parameters such as fetal weight, placental weight and Na+, K+‐ATPase activity in the placental tissue were significantly depressed in SHRSP, especially in the salt‐loaded SHRSP compared with WKY. 3. Besides a decrease of blood flow, a decline of Na+, K+‐ATPase activity associated with an active transport of amino acid in the placenta would cause IUGR and SFD in the salt‐loaded pregnant SHRSP. 4. Pregnant SHRSP given water containing salt would be a good model for pregnancy induced hypertension in humans.Keywords
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