Lymphocyte capping: A diagnostic method in progressive muscular dystrophy?

Publisher Website
Google Scholar
Abstract
Antibody-induced redistibution (capping) of membrane antigens of B-lymphocytes is subnormal in patients with progressive muscular dystrophy. The study was primarily designed to verify or refute claims that such an abnormally low capping capacity can be used to diagnose this disease group. In 8 dystrophy patients the median capping was reduced to 40%, while it was 52% in 27 neurological control patients and 62% in 20 healthy blood donors. There was considerable overlap between the capping percentages of the 3 groups. The demonstration of reduced lymphocyte capping in the individual patient is of little, if any, diagnostic value.