Cyclin-Dependent KinasesInitial Approaches to Exploit a Novel Therapeutic Target

• 1 May 1999
• journal article
• review article
• Published by Elsevier in Pharmacology & Therapeutics
• Vol. 82  (2-3) , 285-292
• https://doi.org/10.1016/s0163-7258(98)00062-x

Abstract

Keywords

• FLAVOPIRIDOL
• CYCLIN-DEPENDENT KINASE
• PHASE I TRIAL
• BENZODIAZEPINE
• COMPARE
• DRUG TREATMENT OF NEOPLASMS
• CDK
• DLT
• DOSE-LIMITING TOXICITY
• GI50
• CONCENTRATION INHIBITING CELL GROWTH BY 50%
• MTD
• MAXIMAL TOLERATED DOSE
• NCI
• NATIONAL CANCER INSTITUTE