Sequential Measurements of the Reticulo-Endothelial System Function in Henoch-Schönlein Disease of Childhood: Correlations with Various Immunological Parameters

Publisher Website
Google Scholar
Abstract
Different immunological parameters were studied in 16 children suffering from Henoch-Schonlein purpura. The following results were observed during the acute phases in some patients: an increase in C3d plasma levels; the presence of circulating immune complexes (CIC); an increase in IgA plasma levels and an impairment of the reticuloendothelial system (RES) function assessed by an in vitro and an in vivo test. After the acute phase, all the altered parameters were almost normalized in recovering patients. On the contrary, all 5 patients with persistent urinary findings or relapsing purpura continued to present increased IgA plasma levels and/or CIC and/or impaired RES function. In Henoch-Schonlein disease of childhood, a correlation exists between persisting clinical signs and persisting high IgA plasma levels, CIC and RES function impairment.