Peripheral Vascular Responses to Frostbite as Influenced by Alcohol

Publisher Website
Google Scholar
Abstract
Observations were carried out on the cheek pouch of the hamster, Mesocricetus auratus. Intraperit. injns. of 25% alcohol (0.15 cc.) were effective in alleviating vasoconstriction in postfrostbite, and in preventing vasoconstrictions when given prior to the induction of frostbite. In both cases the effect was temporary, being more prolonged in pretreatment. The action of alcohol suggests that peripheral vasoconstriction is due to the activation of vasomotor centers by injury substances originating at the site of the frostbite. Alcohol depresses the vasoconstrictor action, but vasoconstrictions recur when the alcohol has been dissipated. Blood sludge was observed under conditions of direct frostbite and alcohol treatment. It apparently differs from rouleaux formation in that it is a uniform gel-like mass embracing practically all of the formed elements of the blood.

This publication has 7 references indexed in Scilit: