Loss of Sensitivity to ACTH of Adrenocortical Cells Isolated from Maturing Domestic Fowl

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Abstract
Maturation of domestic fowl corticosteroidogenesis was evaluated using purified adrenocortical cells. Basal corticosterone production decreased steadily from 2 days-26 wk after hatching. However, maximally stimulated corticosterone production was not changed. In contrast, the half-maximal steroidogenic concentrations (ED50 values or effective doses for 50% maximal effect) of ACTH analogs increased .apprx. 40 .times. by 26 wk, but the ED50 values of 8-bromo-cAMP and pregnenolone were not changed. Adrenocortical cell sensitivity to ACTH apparently decreases with maturation of the domestic fowl.

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