SODIUM AND CHLORIDE IN FROG MUSCLE

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Abstract
The Cl contents of plasma and muscles, measured in frogs in normal condition and after immersion in physiologic solutions, vary more than the Na contents with variations in the condition of the frog. Cl appears to be present in a "chloride space" representing normally 14.5% of the total muscle, in which it has the same conc. as that in the plasma. Since the Na/Cl ratio in muscle is nearly twice that in plasma, some of the Na (the "excess Na") must be present in the muscle outside the chloride space. Evidence is presented that this excess Na is less diffusible than the Cl or the rest of the Na. Isolated sartorius muscles immersed in Ringer solution gain large amts. of Cl and only small amts. of Na until the Na/Cl ratio becomes equal to that in Ringer and the Na and Cl "spaces" become equal. It is concluded that Na and Cl can penetrate freely between the muscle fibers in the chloride space but cannot enter the fibers themselves.

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