Effects of Various Amino Acids on Indomethacin-Induced Gastric Ulcers in Rats
Open Access
- 1 January 1977
- journal article
- research article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 27 (2) , 316-319
- https://doi.org/10.1254/jjp.27.316
Abstract
Indomethacin, a potent antiinflammatory agent, frequently induces gastric irritation and ulceration; therefore, clinical application for the treatment of arthritis is not feasible. Various amino acids significantly inhibit gastric ulcers induced by aspirin in pylorus-ligated rats. It was of interest to determine whether or not those amino acids also protect animals with an intact pylorus against indomethacin-induced gastric ulcers. Pretreatment with more than 10 amino acids significantly inhibited the indomethacin-induced gastric ulcers in rats. Since the mechanism involved in the irritation with indomethacin remains unknown, interpretation of the effects of these amino acids on ulceration is difficult. It appears that amino acids having a high alkalinity may inhibit aspirin-induced ulcers by neutralizing the gastric acid accumulated in the stomach and such is considered to be the main causal factor.This publication has 0 references indexed in Scilit: