Effects of Intra-accumbens Administration of Dopamine Agonists on Stress-induced Behavioural Deficit
- 1 February 1990
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 42 (2) , 79-84
- https://doi.org/10.1111/j.2042-7158.1990.tb05358.x
Abstract
The effect of post-footshock injections of (+)-amphetamine, the selective D2-receptor agonist quinpirole (LY 171555), and the D2-receptor antagonist metoclopramide, into the nucleus accumbens, on the formation of the open field deficit, has been studied in rats. Microinjections of (+)-amphetamine (10 μg) stimulated rat locomotor activity tested 5 min later, while quinpirole (10 μg) significantly inhibited animal motility in the test. The open field behaviour was not changed 24 h after injection of either drug. Amphetamine applied immediately after inescapable footshock did not modify stress-induced locomotor depression, when the rats' behaviour was examined 24 h later. On the other hand, post-shock injections of quinpirole significantly attenuated the long-term effects of the stressor, in the open field. Metoclopramide (10 μg) inhibited rat locomotor activity 5 min, but not 24 h, after local injection. Administration of a solution containing both quinpirole (10 μg) and metoclopramide (1 μg) decreased motor activity of unstressed rats to a smaller degree than did quinpirole (10 μg) alone. Post-footshock injection of metoclopramide did not affect stress-induced hypomotility. It is concluded that the present data support the hypothesis that local depletion of brain dopaminergic stores causes some behavioural effects of stressors.This publication has 34 references indexed in Scilit:
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