Diabetic Polyneuropathy: The Importance of Insulin Deficiency, Hyperglycemia and Alterations in Myoinositol Metabolism in Its Pathogenesis

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Abstract
The diabetic neuropathies include a variety of syndromes that differ in their clinical manifestations, prognoses and, in some instances, their pathologic bases. Distal symmetrical polyneuropathy, the most common form of diabetic neuropathy, is a major cause of morbidity in diabetic persons and can have a primary role in the development of foot ulcers. At present, there is no effective means for prevention or treatment of diabetic polyneuropathy, and its pathogenesis is unknown. Neuropathological studies have excluded occlusive arterial disease and diabetic "microangiography" as major factors, and most workers now believe that the development of this syndrome is conditioned by some . . .