The Cellular Basis of Cross-Tolerance
Open Access
- 1 September 1973
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 111 (3) , 805-810
- https://doi.org/10.4049/jimmunol.111.3.805
Abstract
Mice made unresponsive to human γ-globulin demonstrate a marked cross-tolerance to porcine γ-globulin and equine γ-globulin but react normally to the more phylogenetically distinct chicken γ-globulin. This cross-tolerance exists in spite of an antigenic cross-reactivity at the indirect plaque-forming cell level of only 1 to 3%. This cross-tolerance status can be transferred to thymectomized, irradiated, bone marrow-reconstituted recipients by tolerogen-treated thymus cells. It is suggested that antigen recognition by the thymus-derived cell manifests a wider range of cross-reactivity than that evidenced by the bone marrow-derived cell.Keywords
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