CHRONIC VITAMIN A POISONING

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Abstract
Hypervitaminosis A is a syndrome first described by Josephs in 1944.1 Subsequently, there have been 13 additional cases reported.2 Observers have noted the following characteristic manifestations of the entity: external cortical thickenings of the affected bones, pain and swelling over the long bones, irritability and fretfulness, and increased vitamin A concentration in the blood. REPORT OF CASE B. Z., a 28-month-old white child, was first seen by me on April 15, 1950, after he had been ill at home for two and one-half weeks. His main complaints were painful swellings of the left foot, right forearm, and temporal regions. He also complained of severe itching of the back and arms. At the onset, although limping, the child was able to get around, but within a few days the pain became so severe that he refused even to attempt to walk. Penicillin and aureomycin were administered during the first
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