Effect of Temperature on the Growth Curves of Herpes Simplex Virus in Tissue Culture

Open Access
Publisher Website
Google Scholar
Abstract
Since recurrent herpes simplex infections in man can be precipitated in 40 to 70% of the general population by elevation of the bodily temperature (1, 2), it seems likely that temperature has an important effect, either directly or indirectly, upon the host-herpes simplex virus relationship. In a previous paper (3) we have demonstrated that temperature exerts a significant influence on the amount of herpes simplex virus produced in infected tissue cultures. During a 3-day period of incubation infected cultures kept at 35°C produced large amounts of virus, cultures kept at 30 and 40°C produced intermediate amounts of virus and cultures kept at approximately 25°C and which were produced little or no virus could be made to elaborate increased amounts of virus by raising the temperature of incubation to 35°C. These experiments were done by adding a known amount of virus to cultures and titrating the amount of virus present after 3 days of incubation at the four different temperatures.

This publication has 1 reference indexed in Scilit: