C‐Group Chromosome Abnormalities in Bone Marrow Cells of Three Children with Dyshaematopoiesis of Unknown Origin

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Abstract
Clinical and cytogenetic findings in 3 children with dyshematopoiesis and bone marrow aneuploidy are described. Monosomy 7 was found in immature cells of a 10 yr old boy with myelofibrosis following a 3 yr evolution of severe thrombocytopenia and anemia. Trisomy 8 was found in 80% of the bone marrow metaphases of a 5 1/2 yr old girl with aplastic anemia and Australia antigen positivity. During a 3 yr observation period the number of cells with trisomy 8 regressed and eventually disappeared. Improvement of her clinical condition is present but still limited. Trisomy 8 was also found in all bone marrow cells of an 8 yr old girl with an undefined myeloproliferative disorder. Her disease was apparently related to collagen-vascular disorders like periarteritis or other necrotizing angiitis, and was presented with periods of exacerbation and periods of chronic evolution. Periods of exacerbation were accompanied by excessive myeloid proliferation. Repeated bone marrow cytogenetic analysis during the acute and chronic phases showed trisomy 8 in all metaphase analysed. During the last episode of acute illness, further clonal evolution was observed, characterized by a translocation (8;17).