Synthesis and antianxiety activity of (.omega.-piperazinylalkoxy)indan derivatives

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Abstract
A series of (.omega.-piperazinylalkoxy)indan derivatives were synthesized and screened for potential antianxiety activities in mice. The effect of structural modification of these molecules on activities was systematically examined. Antianxiety activity was displayed by 5-[3-(4-phenyl-1-piperazinyl)propoxy]indan (2), 5-[3-[4-(4-fluorophenyl)-1-piperazinyl]propoxy]indan (8), 6-fluoro-5-[3-(4-phenyl-1-piperazinyl)propoxy]indan (33) and 6-methyl-5-[3-(4-phenyl-1-piperazinyl)propoxy]indan (42), as determined in antifighting and anti-morphine tests. These derivatives in antianxiety tests were equipotent or more potent than chlordiazepoxide with less muscle-relaxant effect. They also showed weak neuroleptic-like action.

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