Control of malignant ascites with spironolactone
- 1 August 1982
- journal article
- research article
- Published by Oxford University Press (OUP) in British Journal of Surgery
- Vol. 69 (8) , 441-442
- https://doi.org/10.1002/bjs.1800690802
Abstract
Thirteen of 15 patients with malignant ascites ashieved an excellent response to spironolactone, with an increase in urinary sodium excretion rates from less than 35 mEq/d before treatment to between 50 and 245 mEq/d after treatment. Plasma renin activity was raised in all of 5 patients in whom it was measured, whereas aldosterone was raised in only 3; these results are similar to those found in ascites due to cirrhosis.Keywords
Funding Information
- Cancer Research Campaign
- Frances and Augustus Newman Foundation
This publication has 13 references indexed in Scilit:
- Renal Sodium Retention in Cirrhosis: Relation to Aldosterone and Nephron SiteClinical Science, 1979
- A quantitative measurement of peritoneal drainage in malignant ascitesCancer, 1977
- Further Experience with Peritoneo-venous Shunt for AscitesAnnals of Surgery, 1976
- Intracavitary bleomycin in the management of malignant effusionsCancer, 1976
- Pathogenesis of Ascites in Mice With Peritoneal Carcinomatosis 2JNCI Journal of the National Cancer Institute, 1976
- Ascites and renal failure in primary liver cell carcinoma.BMJ, 1975
- A Study of Ascites Using Lymphoscintigraphy with99mTc-Sulfur ColloidRadiology, 1973
- Measurement of Renin Activity, Concentration and Substrate in Rat Plasma by Radioimmunoassay of Angiotensin IEndocrinology, 1972
- Intracavitary 5-Fluorouracil in Malignant EffusionsArchives of internal medicine (1960), 1965
- Diuretic Therapy for Malignant EffusionPublished by American Medical Association (AMA) ,1962