Low Levels of γ‐Aminobutyric Acid in Cerebrospinal Fluid of Dogs with Epilepsy
- 1 April 1986
- journal article
- Published by Wiley in Journal of Neurochemistry
- Vol. 46 (4) , 1322-1325
- https://doi.org/10.1111/j.1471-4159.1986.tb00658.x
Abstract
Gamma-Aminobutyric acid (GABA) levels were determined in cisternal cerebrospinal fluid (CSF) of 19 epileptic dogs with generalized tonic-clonic (grand mal) seizures using a radioreceptor assay. Thirty-four healthy age-matched dogs served as controls. The average CSF GABA level in epileptic dogs (40 pmol/ml) was significantly lower than that determined in controls (66 pmol/ml). Treatment with phenobarbital or primidone seemed not to affect CSF GABA levels.Keywords
This publication has 14 references indexed in Scilit:
- Monitoring of γ-Aminobutyric Acid in Human Cerebrospinal FluidTherapeutic Drug Monitoring, 1984
- Cerebrospinal fluid GABA levels in children with infantile spasmsNeurology, 1984
- Alterations in CSF GABA levels and seizure susceptibility developing during repeated administration of pentetrazole in dogs. Effects of γ-acetylenic GABA, valproic acid and phenobarbitalNeurochemistry International, 1983
- Low CSF GABA concentration in children with febrile convulsions, untreated epilepsy, and meningitisZeitschrift für Neurologie, 1983
- Relationship Between GABA Concentrations in Cerebrospinal Fluid and Seizure ExcitabilityJournal of Neurochemistry, 1982
- Amino acid abnormalities in epileptogenic fociNeurology, 1981
- Low cerebrospinal fluid γ‐aminobutyric acid content in seizure patientsNeurology, 1979
- The relationship between GABA concentrations in brain and cerebrospinal fluidBrain Research, 1979
- GABA in plasma and cerebrospinal fluid of different species. Effects of γ‐acetylenic GABA, γ‐vinyl GABA and sodium valproateJournal of Neurochemistry, 1979
- γ‐Aminobutyric acid (GABA) in human cerebrospinal fluid: radioreceptor assayJournal of Neurochemistry, 1977