[Modification of extrapyramidal signs by apomorphine associated with various dopaminergic antagonists].

  • 1 January 1982
    • journal article
    • research article
    • Vol. 138  (5) , 409-13
Abstract
An acute administration of various doses of apomorphine, a dopaminergic agonist, and of dopaminergic receptor blockers (domperidone, sulpiride, haloperidol), was double-blindly achieved in a parkinsonian patient also suffering from dyskinesia. Apomorphine improved tremor and dyskinesia proportionnally to the dose. Domperidone did not prevent from this beneficial effect whereas sulpiride or haloperidol revealed a competitive antagonism versus apomorphine.

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