Exponential Decrease During Aging and Random Lifetime of Mouse Spermatogonial Stem Cells
- 15 December 1978
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 202 (4373) , 1214-1215
- https://doi.org/10.1126/science.725597
Abstract
Variation in the number of spermatogonial stem cells during the lifespan of the mouse was examined by assaying the number of clonogenic cells, that is, spermatogenic stem cells, surviving known doses of radiation. The results indicated that the stem cell number decreased exponentially with age.This publication has 18 references indexed in Scilit:
- γ-ray mutagenesis of cultured mammalian cells in vitro and in vivoMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1977
- Isolation of nutrient deficient mutants and quantitative mutation assay by reversion of alanine-requiring L5178Y cellsMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1976
- Senescence of an Antibody-forming Cell CloneNature, 1972
- Age‐related changes in hematopoietic stem cell populations of a long‐lived hybrid mouseJournal of Cellular Physiology, 1971
- Spermatogonial stem‐cell renewal in the mouseThe Anatomical Record, 1971
- Re‐examination of spermatogonial renewal in the rat by means of seminiferous tubules mounted “in toto”Journal of Anatomy, 1968
- Decline in colony‐forming ability of marrow cells subjected to serial transplantation into irradiated miceJournal of Cellular and Comparative Physiology, 1964
- Review Lectures on Senescence - II. Heterochronic transplantation in the study of ageingProceedings of the Royal Society of London. B. Biological Sciences, 1962