Effect of intrathecal hydrocortisone on advanced adhesive arachnoiditis and cerebrospinal fluid pleocytosis

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Abstract
The effect of intrathecal administration of hydrocortisone on the reticulin network of developing pia-arachnoid adhesion induced by talcum and on cerebrospinal fluid pleocytosis was determined. In most animals, hydrocortisone arrested further development of the reticulin network and of the cellular elements of the adhesions from the time of its administration. The first intrathecal administration of hydrocortisone caused a moderate pleocytosis in the cerebrospinal fluid, whereas subsequent injections produced only a very slight cellular reaction. The results of the present investigation warrant early administration of adrenocortical therapy to patients with developing pia-arachnoid adhesions in order to inhibit further increase and suggest that such therapy, when given intrathecally, does not aggravate the inflammatory process in the subarachnoid space.

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