Antihypertensive activity of bucumolol, a .BETA.-adrenergic blocking agent, in spontaneously hypertensive rats.

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Abstract
Effects of bucumolol, a .beta.-adrenergic blocking agent, on blood pressure and the renin angiotensin system were studied in spontaneously hypertensive rats (SHR). The results were compared with those of propranolol at an equipotent dose in .beta.-adrenergic blocking activity. Bucumolol lowered blood pressure and decreased plasma renin concentration (PRC) in both acute and long-term experiments. There was significant correlation between percent changes in blood pressure and PRC following a single administration of bucumolol. Decrease in PRC persisted for the 6 wk observation period despite the sustained reduction in blood pressure. Propranolol did not lower blood pressure in acute experiments while it decreased renin release. Inhibition of renin may be involved in the antihypertensive action of bucumolol.