HEMOSTATIC DEFECT OF CHRONIC LIVER-DISEASE - KINETIC STUDIES USING SE-75-SELENOMETHIONINE

Google Scholar
  • 1 January 1979
    • journal article
    • research article
    • Vol. 76  (3) , 540-547
Abstract
With the use of cohort labeling with 75Se-selenomethionine, simultaneous platelet, fibrinogen, and plasminogen survival studies were carried out in 8 patients with chronic alcoholic liver disease and in 5 normal subjects. Clinical features, liver function tests, coagulation and fibrinolytic system activities, and platelet function were also assessed. On the basis of platelet survival, the patients could be divided into 2 groups. Three patients had shortened platelet survival. They were all thrombocytopenic and had greater prolongation of the prothrombin time (PT) and activated partial thromboplastin time (PTT) than the other 5 patients. Platelet turnover was decreased in all the patients, and there was no difference betweeen the 2 groups with regard to fibrinogen or plasminogen survival nor in the in vitro evidence of disseminated intravascular coagulation (DIC). Fibrinogen survival was increased in 5 of the 8 patients. Plasminogen survival was normal in 6 patients and prolonged in 2 patients with very low plasminogen levels. The absence of increased fibrinogen turnover in the patients studied indicates that the abnormalities in coagulation tests were not due to consumption coagulopathy. In patients with chronic stable alcoholic liver disease, the concept that the coagulopathy of liver disease is due to increased utilization of clotting factors should be revised with caution.

This publication has 2 references indexed in Scilit: