EFFECT OF THE STREPTOZOTOCIN DIABETES UPON THE INVIVO CONVERSION OF [I C-14] GAMMA-LINOLENIC AND DIHOMO-GAMMA-LINOLENIC ACIDS INTO ARACHIDONIC-ACID IN RATS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 5  (1) , 43-46
Abstract
Streptozotocin diabetic rats were administered the same tracer dose of either [1 14C] .gamma.-linolenic or [1 14C] dihomo-.gamma.-linolenic acid by stomach tube 7 days after streptozotocin injection. They were killed 48 h later and the radioactivity in individual fatty acids of the liver determined by radio-gas chromatography. Results were compared to those obtained in non-diabetic rats similarly prepared. With either radioactive precursor, 14C radioactivity recovered in hepatic dihomo-.gamma.-linolenic acid was not significantly affected by the diabetic state. 14C radioactivity incorporated into arachidonic acid was considerably decreased in diabetic rats, compared with normal rats, when the weights of hepatic arachidonic acid were the same in the 2 groups of animals. Streptozotocin diabetes apparently causes a partial inhibition of the 5-desaturation of dihomo-.gamma.-linolenic acid in rat liver in vivo.

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