Studies on the Liberation of β‐Thromboglobulin from Human Platelets in Vitro

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Abstract
A platelet specific protein, .beta.-thromboglobulin, is liberated during the preparation of platelet poor plasma. Using combinations of different anticoagulant and anti-platelet compounds, this release can be significantly reduced. The best results were obtained when native blood was collected as soon as possible into a mixture of EDTA, prostaglandin E1 and theophylline and maintained and processed at a temperature between 0 and 4.degree. C. These technical innovations permitted the use of a radioimmunoassay for .beta.-thromboglobulin on plasma samples in clinical practice.