The Effect of B-Complex Vitamins on the Voluntary Consumption of Alcohol by Rats

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Abstract
Rats weighing 150-200 g. were maintained on purified diets and allowed to select water or 20% alc. (by vol.) ad lib. When the diet contained casein, sucrose, corn oil, codliver oil and salt mixture supplemented by thiamin, riboflavin, pyridoxine, Ca pantothenate, nicotinamide, choline HC1, p-aminobenzoic acid, i-inositol, biotin, ascorbic acid, 2-methyl-l,4-naphthoquinone, tocopherols and Wilson''s liver fraction L, the rats did not choose alcohol. When the vit. supplements were omitted from the diet the rats consumed relatively large amts. of alc. (10-15 ml. of 20% alc. after a dietary period of 30 days). Once the alc. intake became elevated on a deficient diet it could not be restored perma-nently to low levels by feeding a complete diet; inclusion of missing factors in the diet usually evoked a temporary de- crease in alc. consumption. A diet containing 15% yeast did not prevent an increase in alcohol consumption but gave a temporary decrease when substituted for other diets that had allowed the alcohol intake to rise.

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