Enantiocontrolled Synthesis of Highly Functionalized Tropanes via [5 + 2] Cycloaddition to η3-Pyridinylmolybdenum π-Complexes
- 1 November 2000
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 2 (24) , 3909-3911
- https://doi.org/10.1021/ol000288x
Abstract
A chiral, nonracemic η3-pyridinyl scaffold participates in [5 + 2] cycloaddition with electron-deficient alkenes, an allene, and an alkyne to give η3-allylmolybdenum bicyclic adducts. The adducts can be demetalated, providing a convergent route to highly functionalized tropanes. High enantiocontrol can be achieved throughout the cycloaddition and demetalation sequence.Keywords
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