THE EFFECT OF NORTESTOSTERONE PHENYLPROPIONATE ON COMPENSATORY HYPERTROPHY OF THE REMAINING KIDNEY AFTER UNILATERAL NEPHRECTOMY

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Abstract
Forty eight hours after unilateral nephrectomy, both in non-castrated and in castrated male mice the relative dry weight of the remaining kidney increased significantly. This compensatory hypertrophy was significantly stimulated as early as 96 hours after operation by the treatment with 19-nortest-osterone phenylpropionate (=NPP) at the time of operation. The per-centual increase of the kidney weight was approximately the same in non-castrated as in castrated mice. The absolute initial values as well as the resulting values 96 hours after operation were higher in non-castrated male mice than in castrated animals. The number of cells and the deoxyribonucleic acid (DNA) concentration/g tissue decreased during the period of non-stimulated compensatory hypertrophy in both groups of animals. NPP caused a still further decrease. The concentration of DNA/cell did not change. Following non-stimulated compensatory hypertrophy, there was no change in the RNA concentration/ g tissue or /cell in castrated mice. In non-castrated mice the concentration increased. NPP caused approximately the same percentual increase of RNA concentration in non-castrated as in castrated animals during the period of compensatory hypertrophy. The difference between both groups of mice in the RNA concentration in the remaining kidney following stimulation of the compensatory hypertrophy by NPP was statistically significant.

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