Histamine Release Elicited by Extracts from Ascaris Suis – Influence of Oxygen Lack and Glucose

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Abstract
In guinea pigs intraperitoneal injection of Ascaris extract in doses effective in rats neither released histamine into the peritoneal fluid, nor“disrupted” mast cells in the mesentery. In vitro studies on Ascaris‐induced histamine release from rat lung tissue showed the release to be dependant on pH, incubation time and concentration of extract. Under oxygen lack, the histamine release by Ascaris extract diminished to about 9% of that in oxygen, but increased in the presence of glucose to about 80 % of the values found in the presence of both oxygen and glucose (5.6 mmole/1). With oxygen alone 60 % of this value was released. The enhancement of histamine release caused by glucose in nitrogen as well as oxygen suggests that it is dependant on enzymatic processes yielding high energy compounds.

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