A Scalable, Extrusion-Free Method for Efficient Liposomal Encapsulation of Plasmid DNA
- 21 March 2005
- journal article
- research article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 22 (3) , 362-372
- https://doi.org/10.1007/s11095-004-1873-z
Abstract
A fully scalable and extrusion-free method was developed to prepare rapidly and reproducibly stabilized plasmid lipid particles (SPLP) for nonviral, systemic gene therapy.Keywords
This publication has 47 references indexed in Scilit:
- Low-pH-Sensitive PEG-Stabilized Plasmid−Lipid Nanoparticles: Preparation and CharacterizationBioconjugate Chemistry, 2003
- Pharmacokinetics of Pegylated Liposomal DoxorubicinClinical Pharmacokinetics, 2003
- Influence of transbilayer area asymmetry on the morphology of large unilamellar vesiclesBiophysical Journal, 1995
- Encapsulation of Vincristine in Liposomes Reduces its Toxicity and Improves its Anti-Tumor EfficacyJournal of Liposome Research, 1995
- Modulation of Membrane Fusion by Asymmetric Transbilayer Distributions of Amino LipidsBiochemistry, 1994
- In Vivo Delivery of Human α1-Antitrypsin Gene to Mouse Hepatocytes by LiposomesBiochemical and Biophysical Research Communications, 1993
- Vesicles of variable sizes produced by a rapid extrusion procedureBiochimica et Biophysica Acta (BBA) - Biomembranes, 1986
- Intracellular fate of liposome-encapsulated DNA in mouse liver. Analysis using electron microscope autoradiography and subcellular fractionationBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1985
- Expression of A β-lactamase activity in Mycoplasma capricolum transfected with the liposome-encapsulated E. coli pBR 322 plasmidBiochemical and Biophysical Research Communications, 1982
- A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATIONCanadian Journal of Biochemistry and Physiology, 1959