Directly coupled liquid chromatography with inductively coupled plasma mass spectrometry and orthogonal acceleration time-of-flight mass spectrometry for the identification of drug metabolites in urine: application to diclofenac using chlorine and sulfur detection
- 24 November 2000
- journal article
- research article
- Published by Wiley in Rapid Communications in Mass Spectrometry
- Vol. 14 (24) , 2377-2384
- https://doi.org/10.1002/1097-0231(20001230)14:24<2377::aid-rcm176>3.0.co;2-5
Abstract
No abstract availableKeywords
This publication has 10 references indexed in Scilit:
- High-performance liquid chromatography and inductively coupled plasma mass spectrometry (HPLC-ICP-MS) for the analysis of xenobiotic metabolites in rat urine: application to the metabolites of 4-bromoanilineThe Analyst, 2000
- Protein and Nonprotein Cysteinyl Thiol Modification by N-Acetyl-p-benzoquinone Imine via a Novel Ipso AdductBiochemistry, 1999
- Rapid multi-component detection of fluorinated drug metabolites in whole urine from a ‘cassette’ dose study using high resolution 19F NMR spectroscopyAnalytical Communications, 1999
- NMR Spectroscopy of BiofluidsPublished by Elsevier ,1999
- Selective Protein Adduct Formation of Diclofenac Glucuronide Is Critically Dependent on the Rat Canalicular Conjugate Export Pump (Mrp2)Chemical Research in Toxicology, 1998
- Direct coupling of chromatographic separations to NMR spectroscopyProgress in Nuclear Magnetic Resonance Spectroscopy, 1996
- Diclofenac-associated hepatotoxicity: Analysis of 180 cases reported to the food and drug administration as adverse reactionsHepatology, 1995
- Idiosyncratic Liver Toxicity of Nonsteroidal Antiinflammatory Drugs: Molecular Mechanisms and PathologyCritical Reviews in Toxicology, 1995
- Toward an Epidemiology of Gastropathy Associated With Nonsteroidal Antiinflammatory Drug UseGastroenterology, 1989
- Biotransformation of diclofenac sodium (Voltaren®) in animals and in manXenobiotica, 1979